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      "body": "<html>\n<p>生命有多重要，疫苗就有多重要。为了帮助公众了解疫苗，疾控中心、医院和企业，不断对疫苗安全性保障作出努力，为大众树立了正确的免疫预防理念。 “2016赛诺菲健康加油站”日前在北京召开。中国疾病预防控制中心流行病学首席专家曾光教授表示，持续而广泛地应用疫苗不仅对控制、根除疾病卓有成效，同时疫苗还是最具经济效益的健康投资。</p>\n<p><strong>疫苗预防传染病的价值</strong></p>\n<p>在疫苗发明之前，人类被笼罩在各种传染性疾病的阴影下。疫苗问世以来，免疫接种每年挽救全球300万人的生命，使75万儿童免于残疾。正是基于疫苗在人类和疾病抗争的历史长河中无可替代的作用和价值的深刻认知，世卫组织专门通过官方微博发文，呼吁公众：“接种疫苗，别犹豫”；并对低龄儿童父母提出了最佳建议是：为孩子接种疫苗！疫苗可有效预防传染病，例如脊髓灰质炎（简称脊灰）、白喉、麻疹、百日咳等。疫苗对于全球死亡率和发病率的下降发挥了巨大作用。曾光教授表示，1978年实施计划免疫后，我国儿童计划免疫疫苗的接种率不断上升。通过接种疫苗，我国消灭了天花；脊灰（小儿麻痹症）病例数从1988年的约35万例下降到2015年的51例，从未消除过脊灰野病毒流行的国家也从125个减少到两个。曾光表示，疫苗的价值主要表现在两方面：一是生命价值；二是经济价值。在美国，根据一项成本效益分析显示，疫苗上每投资1美元将节约2-27美元的医疗支出，在11个西欧国家展开的一项调查显示，每个麻疹病例的治疗成本为209-480欧元，而麻疹疫苗接种的成本则仅为每人0.17-0.97欧元。“注射疫苗其实是最具有经济效益的健康投资，但并不是每个人能意识到。”曾光称，“因为大众对疫苗的理解比较难，比如生病打了抗生素，就可以感觉到体温下降了，症状减轻了；但打疫苗，产生的抗体对自身的保护我们不能直观地感受到疫苗接种以后使发病率降低了，家长却很难把接种疫苗跟疾病的发病率相联系。”</p>\n<p><strong>算一算接种疫苗的经济账</strong></p>\n<p>疫苗接种率在我国儿童群体中相对较好，然而对比国外一些数据，发现我国儿童以外的人群，如中老年人群、慢性疾病患者等高危人群的接种率相对较低。其实，算一算疫苗的经济账，就会发现，接种疫苗是预防和控制传染病最经济有效的公共卫生干预措施。以中老年人群易感且危害较重的肺炎疾病为例，2011年发表的北京市一项研究数据指出：接种肺炎疫苗组发生肺炎相关疾病7例，合计发生医疗及相关费用22660.88元；相比较而言，未接种组同期发生肺炎相关疾病37例，合计发生医疗及相关费用481096.20元；接种肺炎疫苗，每投入1 元人民币可产出6.49元的效益。对于预防其他疾病，疫苗是否仍然高效、经济呢？例如，每年预防流感最有效的方法就是接种流感疫苗。美国的一项研究显示：2001-2003年，每年因流感造成的经济负担总共871亿美元（95%CI：472亿—1495亿）：这其中，有64%的经济负担来自于因患流感或因流感导致其他疾病的65岁以上的老年人群。可见，老年人因接种流感疫苗而产生的经济效益最为可观。今年6月，第七届中国慢病管理大会上，国家卫生计生委宣传司司长毛群安呼吁：“慢病管理需要有创新的管理方式。”免疫接种因其安全性高、有效的经济性，也正在成为慢病管理的创新方式之一。曾光教授也指出，香港开展了对36000余名65岁以上的老年慢性病患者接种疫苗后长达64周的流行病学观察，发现联合接种流感疫苗和肺炎链球菌疫苗组的老年人与未接种流感疫苗组相比，死亡率下降35%，而仅接种流感疫苗组的老年人与未接种流感疫苗组相比死亡率下降22%。而且联合接种组的老年人在64周内进入重症监护室的比例，以及医疗花费都是各组老年人中最低的，成本效益极其明显。</p>\n<p><strong>疫苗质量高标准严管理</strong></p>\n<p>赛诺菲巴斯德高级医学总监法国医学博士舒俭德表示，很多国家都在进行新型疫苗的研发以及疫苗可及性的探索，尤其是尚未被攻克的疾病领域。例如登革热作为一种城市传染病，在超过120个国家、覆盖全球半数人口的区域传播，登革热的暴发通常无法预测，暴发时会让这些城市中心的医疗系统陷入瘫痪，影响社会和经济活动。赛诺菲巴斯德历时20年、在15个国家开展了25项临床试验，使登革热疫苗的研发终获成功。舒俭德表示，疫苗技术的持续创新不断推动疫苗的发展，联合疫苗的相继问世，让免疫接种更为便捷和安全。创新的联合疫苗技术不是简单地将任何几种疫苗随意混合而成的，它是一个充满技术含量和挑战性的创新研发过程。联合疫苗代表着未来的发展趋势，我们国家目前联合最多的是五联苗，国外还有六联苗。北京华信医院保健科副主任医师郑东旖表示，在临床工作中，高科技的疫苗技术也为医务人员减轻了工作负担。例如联合疫苗在免疫接种中具有明显的优势。疫苗使婴幼儿的接种针次减少，从而减少因接种产生的不良事件的风险，节省家长往返医院的次数，也相应减少了医生的工作量。国外相关研究显示，针次数量会给接种点医生及家长带来较大影响：每多注射一针，婴幼儿在接种点平均多哭闹0.4-1.0分钟，医生多花费1.7-2.4分钟；家长多往返一次平均付出的成本为25美元。可见，疫苗的创新在不断保护人类健康的同时，也在改变我们的生活。对家庭而言，父母不用请假照顾生病的孩子，因此也减少了额外的医疗支出；对社会而言，可以节省大量的医疗资源，从而减轻政府和社会的负担，节省社会资金。疫苗的安全性一直是公众最关注的话题。赛诺菲巴斯德一直致力于以最高最严格的标准来生产疫苗。不断创新的能力、先进的生产工艺、严格的生产标准、严谨的质检流程、专业的冷链运输、大量的临床试验和应用等环节都是确保疫苗安全有效的重要因素，也是疫苗品质的保证。作为中国政府免疫预防事业的忠实合作伙伴，赛诺菲巴斯德秉承根植中国的目标，并致力于为中国公众提供高品质的安心疫苗。“免疫是一项伟大的公共成就，它挽救了无数儿童的生命，并使数以万计的人们拥有更健康，更长寿的生活。”——曼德拉<br>\n</p>\n</html>",
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      "body": "<html>\n<p>The meningococcal vaccineprotects you from four types of bacteria that causemeningococcal disease. This illness can cause meningitis, an infection of the lining around the brain or spinal cord. It can also cause a blood infection(meningococcal bacteremia),pneumonia, and other problems. Ten percent to 15% of people who are infected with the disease die from it, even if they were treated with antibiotics. As many as 20% of those who survive may have lasting problems such as hearing loss, brain damage, seizures, or loss of limbs.Because this illness is serious, it's important you get vaccinated if you are at risk.You can catch meningococcal infection through close contact with someone who has the bacteria in his or her throat or nose. Early symptoms of both meningitis and blood infection can be confused with the flu or a cold, but symptoms can rapidly become more severe and may include:</p>\n<ul>\n  <li>Sudden high fever</li>\n  <li>Headache</li>\n  <li>Stiff neck</li>\n  <li>Aches</li>\n  <li>Fatigue</li>\n  <li>Purplish rash on arms and legs</li>\n  <li>Other symptoms such as nausea, vomiting, and changes in mental state</li>\n</ul>\n<h2>Which adults should receive the meningococcal vaccine?</h2>\n<p>The CDC recommends you get the vaccine if you are an adult and:</p>\n<ul>\n  <li>Are living in a dorm as a first-year college student</li>\n  <li>Work with meningococcal bacteria in a lab</li>\n  <li>Are in the military</li>\n  <li>Are traveling to or living in a country where meningococcal disease is common, such as in certain parts of Africa</li>\n  <li>Have a damaged spleen, or it's been removed</li>\n  <li>Have an immune system disorder called terminal complement deficiency&nbsp;</li>\n  <li>Are taking eculizumab (Soliris)</li>\n  <li>May have been exposed to meningitis during an outbreak</li>\n</ul>\n<p><strong>If you are age 55 or younger,</strong> you should have the meningococcal conjugate vaccine (MCV4). It should also be taken if you are traveling or living in a country where meningococcus is common or you are part of population with increased risk of outbreakIf it is not available, you can also have the meningococcal polysaccharide vaccine (MPSV4).<strong>If you are age 56 or older,</strong> you should have the MPSV4, the only approved vaccine for this age group.</p>\n<p>Are there any adults who should not get the meningococcal vaccine?</p>\n<p>You shouldn't have either type of meningococcal vaccine if you:</p>\n<ul>\n  <li>Are moderately or seriously ill. Wait until you recover.</li>\n  <li>Have had a serious allergic reaction (called anaphylaxis) to a previous dose</li>\n  <li>Had a severe reaction to any part of the vaccine</li>\n</ul>\n<p>If you are pregnant or have other concerns, ask your doctor which meningitis vaccine is right for you.</p>\n<h2>How and when should you receive the meningococcal vaccine?</h2>\n<p>You receive the MCV4 as a single dose, injected into a muscle. You receive the MPSV4 as a single dose injected under the skin.In most cases, adults only need one dose. But if you remain at risk, you may need a booster.</p>\n<p><br></p>\n<p><strong>关于脑膜炎球菌性脑膜炎</strong><br>\n脑膜炎球菌性脑膜炎是一种细菌形式的脑膜炎，由于围绕大脑和脊髓的很薄的内皮发生严重感染而造成。该病可对大脑带来严重损害，若不加治疗，50%的病人将失去生命。 几种不同的细菌可引起脑膜炎，脑膜炎奈瑟菌是可能造成大规模流行的细菌。已经确定了脑膜炎奈瑟菌的12个血清群，其中有6个（A、B、C、W、X和Y）可引起流行，地理分布及引发疫情的能力因血清群而异。</p>\n<h3>传播途径及症状</h3>\n<p>细菌通过携带者的呼吸道或者咽喉分泌物飞沫在人间传播。密切接触及长时间接触，比如接吻、打喷嚏或者面向别人咳嗽，或者与感染者（携带者）一起近距离生活（如住在一个宿舍，共用餐饮用具），易于引起疾病传播。潜伏期平均为4天，但可为2天或10天不等。脑膜炎奈瑟菌仅感染人类，不存在动物宿主。这种细菌可以留在喉咙部位，有时，由于尚未完全了解的原因，病菌可以突破身体的防御，使感染通过血流扩散到大脑。据认为，10%至20%的人群咽喉部一直携带脑膜炎奈瑟菌。然而，在发生疫情时，病菌携带率可能会更高。</p>\n<h3>脑膜炎球菌疫苗（流脑疫苗）</h3>\n<h3>目前可用几种疫苗来控制这一疾病，它们是：A群脑膜炎球菌结合疫苗、C群结合疫苗、四价（A、C、Y和W群）结合疫苗和脑膜炎球菌多糖疫苗。</h3>\n<p>我国已上市疫苗种类：• 脑膜炎球菌多糖疫苗（包括：A群单价,A群C群二价和ACYW135群四价）• A群C群脑膜炎球菌结合疫苗• A群C群脑膜炎球菌+b型流感嗜血杆菌联合疫苗国际上已上市疫苗种类：• 脑膜炎球菌多糖疫苗（包括：A群、B群、A群C群二价、ACYW135群四价、联合疫苗等）• 脑膜炎球菌结合疫苗(包括:C群单价, C群脑膜炎球菌+b型流感嗜血杆和ACYW135群四价)<br>\n</p>\n<h3>哪些成人应接种脑膜炎球菌疫苗？</h3>\n<p>推荐以下成人应接种:</p>\n<ul>\n  <li>与大一新生共处；</li>\n  <li>从事与脑膜炎球菌相关的实验室工作人员；</li>\n  <li>军队服役人员；</li>\n  <li>前往或居住于脑膜炎球菌性脑膜炎多方地区，如非洲部分地区；</li>\n  <li>患有脾损伤或者移除者；</li>\n  <li>免疫系统紊乱者；</li>\n  <li>疫情爆发期可能发生暴露者；</li>\n</ul>\n<p><strong>如果年龄低于55周岁（含），应接种四价结合疫苗，如暂无此类疫苗，可使用四价多糖疫苗代替；如果年龄高于56周岁（含），应接种四价多糖疫苗（仅此类疫苗批准用于高年龄组人群）。</strong></p>\n<h3>是否有部分成人不能接种脑膜炎球菌疫苗？</h3>\n<p>以下人群不能够接种：</p>\n<ul>\n  <li>患有中度或严重疾病者，应等痊愈后再接种；</li>\n  <li>以往接种时有严重过敏反应者；</li>\n  <li>对疫苗任一组分有严重反应者；</li>\n</ul>\n<p>如果是怀孕期或有其他症状时，应遵照医生建议选择接种疫苗类型。</p>\n<h3>应如何接种脑膜炎球菌疫苗？</h3>\n<p>四价脑膜炎球菌结合疫苗经肌肉注射接种1剂，四价脑膜炎球菌多糖疫苗经皮下接种1剂。多数情况下成人仅需接种1剂，但若处于高风险环境下，应需加强1剂。资料来源1. WHO网站“<strong>脑膜炎球菌性脑膜炎”</strong>实况报道 第141号2.美国疾控中心网站</p>\n</html>",
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