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      "author": "steemitboard",
      "permlink": "steemitboard-notify-simul-20190525t190841000z",
      "title": "",
      "body": "Congratulations @simul! You received a personal award!\n\n<table><tr><td>https://steemitimages.com/70x70/http://steemitboard.com/@simul/birthday3.png</td><td>Happy Birthday! - You are on the Steem blockchain for 3 years!</td></tr></table>\n\n<sub>_You can view [your badges on your Steem Board](https://steemitboard.com/@simul) and compare to others on the [Steem Ranking](http://steemitboard.com/ranking/index.php?name=simul)_</sub>\n\n\n###### [Vote for @Steemitboard as a witness](https://v2.steemconnect.com/sign/account-witness-vote?witness=steemitboard&approve=1) to get one more award and increased upvotes!",
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      "author": "steemitboard",
      "permlink": "steemitboard-notify-simul-20180525t192156000z",
      "title": "",
      "body": "Congratulations @simul! You have received a personal award!\n\n[![](https://steemitimages.com/70x70/http://steemitboard.com/@simul/birthday2.png)](http://steemitboard.com/@simul)  2 Years on Steemit\n_Click on the badge to view your Board of Honor.\n\n\n> Do you like **SteemitBoard**'s project? **[Vote for its witness](https://v2.steemconnect.com/sign/account-witness-vote?witness=steemitboard&approve=1)** and **get one more award**!",
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      "permlink": "re-simul-re-steemship-how-close-is-steemit-to-going-viral-20160603t043639039z",
      "title": "",
      "body": "@@ -76,16 +76,113 @@\n h to try\n+, though the payout difference largely reflects who voted on it and how much steem power they had\n . The tr\n",
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      "permlink": "re-simul-re-steemship-how-close-is-steemit-to-going-viral-20160603t043639039z",
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      "body": "@@ -37,9 +37,9 @@\n  don\n-;\n+'\n t fe\n",
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      "body": "You'll have to read more about it. I don;t feel I can explain it well enough to try. The truth is that we're all still learning, and the system itself is still undergoing some tweaking. See the current top post from Dan for more info.",
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      "body": "How did VIP's in the real world become VIPs?\nThe deliver extraordinary  service!",
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      "body": "How does one become \"prominent\" in steem?",
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      "author": "simul",
      "permlink": "re-steemship-how-close-is-steemit-to-going-viral-20160602t135419973z",
      "title": "",
      "body": "@@ -63,24 +63,40 @@\n with 2 votes\n+, tons of views,\n  and $0.   I\n",
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      "body": "How does the voting system really work?   I see nice articles with 2 votes and $0.   I see crummy memes, with 12 votes and $100?",
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      "parent_permlink": "technology",
      "author": "simul",
      "permlink": "curing-scid-how-much-is-your-childs-life-worth",
      "title": "Curing SCID : How much is your child's life worth?",
      "body": "Gene therapy's first approved cure is coming, the question is: How much will it cost?\n\nSCID is also known the \"bubble boy\" disease.   Born without a functioning immune system, children with SCID mutations can expect to live shortened lives filled with isolation, risky bone marrow transplants, and painful injections.  If treatment is successful, SCID children can live to adulthood.   If not, the resulting scarring and damage to organs can result in a very early death.  And yet the genetic error that leads to this disease is often a simple mutation in a [single \"ADA\" gene](https://en.wikipedia.org/wiki/Adenosine_deaminase_deficiency).\n\n![](https://i.imgur.com/R7oSLlU.jpg)\n\nNow GlaxoSmithKline (GSK) [has been approved]( http://www.streetinsider.com/Corporate+News/UPDATE%3A+Glaxo+%28GSK%29+Receives+Positive+EMA+CHMP+Opinion+for+Strimvelis+as+ADA-SCID+Treatment/11466081.html) to sell a cure for this disease in the form of gene therapy.   This is the first time an ex-vivo gene therapy will be approved, and will likely become the standard of care for the disease.\nGene therapy represents a new treatment paradigm.   Using viruses to deliver genetic payloads, patients with genetic disorders can have the defective regions of their DNA repaired, replaced or otherwise corrected.   Done right, this represents a true \"cure\" - a word rarely used in modern medicine, because the cells will continue to function correctly over time.\n\nAvigen was an early player in the gene therapy space.  I invested in Avigen more than 10 years ago, and followed closely as it boomed and busted.   Gene therapy proved more difficult than originally thought.   Apparently the body can mount a vigorous immune response both against viral vectors, and, in many patients, this prevents the cure from being delivered.\n\nToday, a new technique, called \"ex-vivo\" gene therapy, appears to be a success.   Treatment involves removing stem cells from the body, treating them for the genetic disease, and re-implanting them.   These modified stem cells, long lived and dividing rapidly, then produce corrected versions of the patient’s defective proteins.  This method is safer because the genetic treatment occurs in a controlled, monitored environment - free of immune response and subject to rigorous testing before re-implantation.\n\nIt's been over 10 years since the treatment was first developed - a testament to how difficult the regulatory environment is for gene therapy.   Glaxo's treatment, Strimvelis, received a favorable opinion in April by the European Medicines Agency, and [trial results just released have been impressive]( http://www.lse.co.uk/AllNews.asp?code=wrpvw3l1), with 15 intervention-free children attending school.\n\nThe ugly question on the table is: how much do you charge for such a dramatic cure?  ADA-SCID patients that fail transplants receive expensive injections for the rest of their lives.   Many die.  Almost none of them live what we would consider “normal” lives.   \n\nIn 2012, a similar generic treatment called Glybera was priced at $1 million.   It too provided a \"one shot cure\" for a rare, debilitating disease.   But the drug has been called a [commercial failure]( https://www.technologyreview.com/s/601165/the-worlds-most-expensive-medicine-is-a-bust/), largely because the up-front payment is not a guarantee of success and insurers don't want to bear the cost now for a patient that will not be insured by them in a few years.\n\nAll of which leads to the question: if a child fails a bone marrow transplant, what should Glaxo charge for what amounts to the only chance they have at life?\n\nIn my opinion, the best method proposed has been [\"pay-for-performance\"](http://www.reuters.com/article/us-usa-healthcare-payments-idUSKBN0LN08H20150219).   By tracking patient outcomes, this model rewards drug companies for maintaining patients’ health over a period of time.  Tracking and verifying health metrics, issuing invoices, and collecting payments in this model will become an important business for the medical billing industry.   Insurance companies would then pay for this continued care... with liability passed to later insurers - rather than being incurred by the initial insurer.   \n\nPerhaps the hope for cure to this and thousands of other genetic diseases is not really in the hands of researchers.  The technology is here, it works and has been proven.   It's the financial, insurance, regulators and medical billing companies that have to come together to make gene therapy a reality.\n\n![](https://i.imgur.com/bH8zgJd.jpg)\n\n.",
      "json_metadata": "{\"image\":[\"https://i.imgur.com/R7oSLlU.jpg\"],\"links\":[\"https://en.wikipedia.org/wiki/Adenosine_deaminase_deficiency\",\"http://www.streetinsider.com/Corporate+News/UPDATE%3A+Glaxo+%28GSK%29+Receives+Positive+EMA+CHMP+Opinion+for+Strimvelis+as+ADA-SCID+Treatment/11466081.html\",\"http://www.lse.co.uk/AllNews.asp?code=wrpvw3l1\",\"https://www.technologyreview.com/s/601165/the-worlds-most-expensive-medicine-is-a-bust/\",\"http://www.reuters.com/article/us-usa-healthcare-payments-idUSKBN0LN08H20150219\"]}"
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      "author": "xav",
      "permlink": "re-simul-re-steemservices-new-steemit-images--feel-free-to-use-20160525t211158825z",
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      "body": "Apparently imgur is blocking hotlinking to steemit",
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      "parent_author": "ozmaster",
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      "author": "simul",
      "permlink": "re-ozmaster-vtc-vertcoin-charts-and-comment-20160525t204110742z",
      "title": "",
      "body": "how'd you get images to work?   everyone else's are broken",
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      "author": "simul",
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      "body": "@@ -81,8 +81,186 @@\n  future?\n+   Also, image links aren't always working...  they like work... and then stop working.   see https://steemit.com/technology/@simul/curing-scid-how-much-is-your-childs-life-worth\n",
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      "body": "Why do posts and comments say \"4 hours from now\".... like stuff is posted in the future?",
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      "author": "simul",
      "permlink": "curing-scid-how-much-is-your-childs-life-worth",
      "title": "Curing SCID : How much is your child's life worth?",
      "body": "Gene therapy's first approved cure is coming, the question is: How much will it cost?\n\nSCID is also known the \"bubble boy\" disease.   Born without a functioning immune system, children with SCID mutations can expect to live shortened lives filled with isolation, risky bone marrow transplants, and painful injections.  If treatment is successful, SCID children can live to adulthood.   If not, the resulting scarring and damage to organs can result in a very early death.  And yet the genetic error that leads to this disease is often a simple mutation in a [single \"ADA\" gene](https://en.wikipedia.org/wiki/Adenosine_deaminase_deficiency).\n\n![](https://i.imgur.com/R7oSLlU.jpg)\n\nNow GlaxoSmithKline (GSK) [has been approved]( http://www.streetinsider.com/Corporate+News/UPDATE%3A+Glaxo+%28GSK%29+Receives+Positive+EMA+CHMP+Opinion+for+Strimvelis+as+ADA-SCID+Treatment/11466081.html) to sell a cure for this disease in the form of gene therapy.   This is the first time an ex-vivo gene therapy will be approved, and will likely become the standard of care for the disease.\nGene therapy represents a new treatment paradigm.   Using viruses to deliver genetic payloads, patients with genetic disorders can have the defective regions of their DNA repaired, replaced or otherwise corrected.   Done right, this represents a true \"cure\" - a word rarely used in modern medicine, because the cells will continue to function correctly over time.\n\nAvigen was an early player in the gene therapy space.  I invested in Avigen more than 10 years ago, and followed closely as it boomed and busted.   Gene therapy proved more difficult than originally thought.   Apparently the body can mount a vigorous immune response both against viral vectors, and, in many patients, this prevents the cure from being delivered.\n\nToday, a new technique, called \"ex-vivo\" gene therapy, appears to be a success.   Treatment involves removing stem cells from the body, treating them for the genetic disease, and re-implanting them.   These modified stem cells, long lived and dividing rapidly, then produce corrected versions of the patient’s defective proteins.  This method is safer because the genetic treatment occurs in a controlled, monitored environment - free of immune response and subject to rigorous testing before re-implantation.\n\nIt's been over 10 years since the treatment was first developed - a testament to how difficult the regulatory environment is for gene therapy.   Glaxo's treatment, Strimvelis, received a favorable opinion in April by the European Medicines Agency, and [trial results just released have been impressive]( http://www.lse.co.uk/AllNews.asp?code=wrpvw3l1), with 15 intervention-free children attending school.\n\nThe ugly question on the table is: how much do you charge for such a dramatic cure?  ADA-SCID patients that fail transplants receive expensive injections for the rest of their lives.   Many die.  Almost none of them live what we would consider “normal” lives.   \n\nIn 2012, a similar generic treatment called Glybera was priced at $1 million.   It too provided a \"one shot cure\" for a rare, debilitating disease.   But the drug has been called a [commercial failure]( https://www.technologyreview.com/s/601165/the-worlds-most-expensive-medicine-is-a-bust/), largely because the up-front payment is not a guarantee of success and insurers don't want to bear the cost now for a patient that will not be insured by them in a few years.\n\nAll of which leads to the question: if a child fails a bone marrow transplant, what should Glaxo charge for what amounts to the only chance they have at life?\n\nIn my opinion, the best method proposed has been [\"pay-for-performance\"](http://www.reuters.com/article/us-usa-healthcare-payments-idUSKBN0LN08H20150219).   By tracking patient outcomes, this model rewards drug companies for maintaining patients’ health over a period of time.  Tracking and verifying health metrics, issuing invoices, and collecting payments in this model will become an important business for the medical billing industry.   Insurance companies would then pay for this continued care... with liability passed to later insurers - rather than being incurred by the initial insurer.   \n\nPerhaps the hope for cure to this and thousands of other genetic diseases is not really in the hands of researchers.  The technology is here, it works and has been proven.   It's the financial, insurance, regulators and medical billing companies that have to come together to make gene therapy a reality.\n\n![](https://i.imgur.com/bH8zgJd.jpg)\n\n.",
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