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      "body": "Summary\n- Ameluz (nano emulsion) is superior to former formulation Levulan (actinic kreatoses) and Metvix (basal cell carcinoma).\n- FDA approval for Ameluz as treatment for basal cell carcinoma is likely to follow.\n- Biofrontera is a small German biotech company with growth rate over 80% in sales in the last years.\n- Anchor investor Deutsche Balaton AG seeking 25% ownership.\n\n\n\n\nIt has never been easy for Biotech Startups. Research and development costs have always been incredibly high. Moreover, pharmaceutical products are highly regulated by public department such as the FDA (USA) and EMA (Europe). However, Biofrontera is the first German, founder-led (Prof. Dr. Hermann Lübbert) pharmaceutical company to obtain both EU and U.S. approval for a medical drug it has developed itself. The journey has been long since the Biofrontera Group was founded in 1997 and listed in the Frankfurt Stock Exchange (Prime Standard). \n\n\n\nToday Biofrontera is also listed in the NASDAQ with a market capitalization of 268 Mio. € or 327 Mio. $. Its first product Ameluz is approved for actinic kreatoses in Europe and USA.\n\n\n\nActinic keratosis is a pre-cancerous patch of thick, scaly, or crusty skin. These growths are more common in fair-skinned people and those who are frequently exposed to the sun. They are usually formed when skin gets damaged by ultraviolet (UV) radiation from the sun or indoor tanning beds. Generally, Levulan, which contains 5-aminolaevulinic acid (ALA) with photo dynamic therapy is used. Ameluz is a novel formulation of the same compound as nano scale vesicle in a emulsion. However, the new approach has been shown to chemically stabilize the drug and increase liposomal penetration. For instance, nanoemulsion/nanocolloidal formulations of this drug have been observed to be superior to methyl aminolevulinate (MAL) or Metvix in the treatment of actinic keratoses (complete clearance 78.2% versus 64.2%, respectively) and field cancerization. Before that, MAL is reported to have increased lipophilicity and deeper skin penetration when compared to ALA.  \n\n\n\nMAL is also used in photo dynamic therapy as a treatment option for superficial and thin nodular BCC (thickness <2 mm). In Phase III clinical trials, Ameluz achieved higher clearing rates of all BCCS in comparison with Metvix, 93.4% and 91.8%, respectively. Therefore, Ameluz is already approved by the European medicine agency (EMA) in 2017. \n\n\n\nSince the market launch, sales numbers are raising exponentially and Biofrontera is expected to be profitable by the end of 2018. In the last sales release, the preliminary unaudited revenues of Biofrontera group for the three-month period, from January to March 2018, were between 4.6 and 4.7 million €. This corresponds to a sales growth of approx. 80% compared to the previous year, with pure product sales increase by approximately 107%. \n\n\n\nSince the IPO in the USA, a lot of hype have been created around Biofrontera. One of the anchor investor Deutsche Balaton AG has publicly announced to buy another 6,250,000 shares (14%) of the company. Deutsche Balaton AG is an investment company with a market cap over 200 mio. €. \n\nConclusion:\n\n- Ameluz has proven under clinical trials to be superior in comparison with other treatments\n- Biofrontera is in an enormous growth phase \n- There is a big buy back rate from former and anchor shareholders \n\nDisclosure: I am long Biofrontera.",
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      "body": "<html>\n<p>Congratulations <a href=\"/@s1241003\" target=\"_blank\">@s1241003</a>, you have decided to take the next big step with your first post! The Steem Network Team wishes you a great time among this awesome community.</p>\n<hr>\n<div class=\"pull-left\"><img src=\"https://steemitimages.com/DQmaAdLUJ3yaSkmcmWECWyPGPWcjfbCoZ8Tu4RM6H4DbjCi/steem-network-thumbs-up.gif\" alt=\"Thumbs up for Steem Network´s strategy\" title=\"I suggest Steem Network´s strategy\" width=\"320\" height=\"222\"></div>\n<h1>The proven road to boost your personal success in this amazing Steem Network</h1>\n<p>Do you already know that awesome content will get great profits by following these <a href=\"/steem-network/@steem-network/spread-your-posts-through-this-proven-strategy-and-get-great-profits-in-return--for-posts-created-at-2018-01-19\" target=\"_blank\" alt=\"Steem Network\" title=\"Follow Steem Network´s suggestions to boost your success\">simple steps</a>, that have been worked out by experts?</p>\n</html>",
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      "title": "How much Steem has my favoured Steemian?",
      "body": "Dear Steemians,\n I'm basically super new to this plattform, so you can call me a Newbee/Noob etc.  However I can code a bit, so I did scrolled around until I found out, that Steemit has an API (Application programming interface). An API is pretty usefull. Let's have a demonstration.\n\nHere is a video, where api is very well explained (much better than I can do):\n (https://www.youtube.com/watch?v=7YcW25PHnAA&t)\n\nSo let's have a look on the developer page:\n\nhttps://developers.steem.io/\n![](https://steemitimages.com/DQmTzSR4ZNVhF9uiL2HUowGu2wR3vsDnNWvwZymaWU572AM/image.png)\n\nThe Stuff on the right site is pretty interesting:\n![](https://steemitimages.com/DQmVw23fxH5AnjnV2ZWzJWwh1Ey4miAtHKS45tKWLjEQG4h/image.png)\n\nOk, it's pretty simple huh. There is a user object, which contains your steem information. \n\nJust simply add '.json' at the end of the steemit account.\n\nHere are some examples:\n\nAt first I want to check my own balance. To do that. Just copy to your browser:\n\nhttps://steemit.com/@s1241003.json\n\n![](https://steemitimages.com/DQmXxMHBP7gy6YwoSvuSgTgT1X9hghLFAthsfk4eGwM1JBe/image.png)\n![](https://steemitimages.com/DQmUji5QwHLpa4A6mLKkby267EgXFPaMv2SeE4117jr6SBq/image.png)\n\nOk, my new account is pretty empty.\n\nNow lets find someone chilly to test it out. Let's have a look in the food section. Ok, this girl seems to be nice @sweetsssj \n\nhttps://steemit.com/@sweetsssj.json\n\n![](https://steemitimages.com/DQmdNA5vVhFmGwEuvDJFwcN9ptq1gqpVygJimvPL9CdYBm6/image.png)\n\nOkay, that's some nice numbers. I hope I can get there some day :-D\n\nPlease like and follow me for more tutorials.",
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      "permlink": "how-much-steem-has-my-favoured-steemer",
      "title": "How much Steem has my favoured Steemian?",
      "body": "@@ -8,14 +8,11 @@\n eemi\n-t-User\n+ans\n ,%0A I\n@@ -85,17 +85,17 @@\n bee/Noob\n-%0A\n+ \n etc.  Ho\n@@ -147,14 +147,8 @@\n und \n-a bit \n unti\n@@ -166,17 +166,17 @@\n ut, that\n-%0A\n+ \n Steemit \n@@ -248,28 +248,40 @@\n usef\n-all %0Ain many cases. \n+ull. Let's have a demonstration.\n %0A%0AHe\n@@ -301,18 +301,19 @@\n , where \n+ap\n i\n-t\n  is very\n@@ -411,93 +411,50 @@\n t)%0A%0A\n-An API is also pretty powerfull, if you use it in the right way. So let's have a look\n+So let's have a look on the developer page\n :%0A%0Ah\n@@ -715,21 +715,16 @@\n ng)%0A%0AOk,\n- lets\n  it's pr\n@@ -742,36 +742,210 @@\n  huh\n-, so let's see how much I go\n+. There is a user object, which contains your steem information. %0A%0AJust simply add '.json' at the end of the steemit account.%0A%0AHere are some examples:%0A%0AAt first I want to check my own balance. To do tha\n t. J\n@@ -970,16 +970,17 @@\n rowser:%0A\n+%0A\n https://\n@@ -1194,18 +1194,10 @@\n Ok, \n-so it is a\n+my\n  new\n@@ -1209,60 +1209,26 @@\n unt \n-so the listing is pretty much 0 everywhere :-(%0A%0AOk. \n+is pretty empty.%0A%0A\n Now \n@@ -1320,17 +1320,16 @@\n his girl\n-y\n  seems t\n",
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