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      "author": "steemitboard",
      "body": "Congratulations @mortaladin! You received a personal award!\n\n<table><tr><td>https://steemitimages.com/70x70/https://steemitboard.com/@mortaladin/birthday2.png</td><td>Happy Birthday! - You are on the Steem blockchain for 2 years!</td></tr></table>\n\n<sub>_You can view [your badges on your Steem Board](https://steemitboard.com/@mortaladin) and compare to others on the [Steem Ranking](https://steemitboard.com/ranking/index.php?name=mortaladin)_</sub>\n\n\n###### [Vote for @Steemitboard as a witness](https://v2.steemconnect.com/sign/account-witness-vote?witness=steemitboard&approve=1) to get one more award and increased upvotes!",
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      "body": "Vit D is an important issue in Austism, and your point about the requirement for D3 in serotonin production is not to be ignored. But I don't believe it plays as a role as the paper suggests. Vagal macrophage transmission of bacteria into the brain appears to be a key component in Vitamin D receptor inactivation. until you reactivate the VDR or GC receptors the Vit D cannot do its job correctly.",
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      "body": "addition of fiber is a good thing here. You're going to need it to help your liver eliminate the bile that  sequesters this endocrine modifying chemical laden toxin (phenylketonuric) containing non refreshing 'refreshment', or its glycation inducing older sibling. They both should be avoided unless you like your proteins denatured, misfolded or glycated. Good luck with that",
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      "body": "akarta, (Antara Sumbar) - Menteri Koordinator Bidang Kemaritiman Luhut Binsar Pandjaitan menyebut Badan Pengkajian dan Penerapan Teknologi (BPPT) memiliki teknologi untuk mengatasi masalah kelangkaan garam yang terjadi saat ini.\nLuhut seusai acara penganugerahan gelar Perekayasa Utama Kehormatan di Gedung BPPT, Jakarta, Kamis, mengatakan teknologi itu akan dibahas dalam rapat bersama Menteri Riset, Teknologi, dan Pendidikan Tinggi Mohamad Nasir.\n\"Ternyata BPPT itu sudah sangat bisa bikin garam. Selama ini belum. Akhirnya tadi saya lapor Wakil Presiden, saya besok rapat dengan ahli garam dari tempatnya Pak Menristek Dikti. Ternyata bisa, murah meriah, 'cost' (biaya) rendah. Tanpa melihat cuaca,\" katanya.\nLuhut menuturkan jika teknologi itu layak, diharapkan bisa langsung diimplementasikan. Terlebih jika benar biayanya bisa lebih rendah dan tidak terpengaruh cuaca.\n\"Sehingga produksinya bisa kita angkat sehingga kita tak perlu impor lagi,\" katanya.\nIa merencanakan hasil teknologi BPPT untuk bisa menghasilkan garam itu bisa mulai dilakukan di Kupang, Nusa Tenggara Timur.",
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      "body": "Hi. I am a volunteer bot for @resteembot that upvoted you.\nYour post was chosen at random, as part of the advertisment campaign for @resteembot.\n@resteembot is meant to help minnows get noticed by re-steeming their posts\n-----\nTo use the bot, one must follow it for at least 3 hours, and then make a transaction where the memo is the url of the post.\nIf you want to learn more - [read the introduction post of @resteembot](https://steemit.com/resteembot/@resteembot/how-to-use-resteembot).\nIf you want help spread the word - [read the advertisment program post](https://steemit.com/resteembot/@resteembot/how-to-help-resteem-bot-spread-the-word).\n-----\nSteem ON!",
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      "body": "![](https://steemitimages.com/DQmW2YW8ZoY77NU4qFFQBGDJr4LcWdk68JY3JsiEhaqLawA/image.png)\n\nNext time you think that you should give up or cut back on coffee maybe have a think about this. \nCoffee is a health food. Due the poor quality of nutrition in the average western diet, coffee has  become the foundation for provision of antioxidants so sorely lacking. We each need close to 2000mg of polyphenols or flavinoids to maintain cellular function, mitochondrial repair, or microbiome support. \nCoffee does a darn fine job in providing the base for this need. Each cup of brewed coffee provides 400-450mg polyphenols. Before you get too snobby about freeze dried instant coffee, it comes in at 300-350mg. So bang for buck is still a winner. Thus having 2-3 cups per day will get you half way to providing your necessary intake of polyphenols. Now you only need to eat 7 more servings of brightly coloured  or green veges\nBut there is a proviso with this. These polyphenols are only accessible if you take the coffee without caseinates (found in milk). The casein binds with them and locks them away. Maybe you should consider the long black, or the weird as it may sound, black coffee with butter, ghee or coconut milk or coconut oil. \nSo what about the coffee makes it so special?\nAccording to Prof Mark Smith of Case Western university, it helps to modify Alzheimer's disease.  In his paper “Therapeutic opportunities for caffeine in Alzheimer's Disease and other neurodegenerative disorders” in  the Journal of Alzheimer's Disease, he states “the consumption of moderate amounts of caffeine was inversely associated with the cognitive decline associated with aging as well as the incidence of Alzheimer's disease....\nCaffeine seems particularly effective to normalize rather than bolstering memory performance and is a candidate disease modifying agent for Alzheimer's Disease, based on its neuroprotective profile and its ability to reduce amyloid beta production.” In his eyes, moderate consumption was 5 cups per day. \nSo, do the Java Jive to  reduce your chances of joining the 'Walkers', and do your bit to reduce the horrendous cost Alzheimer's Disease is going to have on your Children and Grandchildren's future.",
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      "body": "Sauna use can improve your longevity.\nThis might sound totally weird, but these are some great reasons to consider Sauna use. The longevity issue is hard to prove, but this is more a case of risk factor mitigation to prolong life. Some research was done on Finnish men, with a couple of studies published from the same data set which showed the following:-\nyou can reduce your risk of myocardial infarction if you sauna 2-3 /week by 27% , and 4-7/week by 50%.\nSauna use lowers all cause mortality by 24-40% (4-7/wk).\nSauna use is like a work out. It increases cardiac output and heart rate by up to 100bpm for moderate session, 150bpm for intense session. The heat stress induced increases blood flow;long term use improves Blood pressure.\n\nWant to improve your exercise tolerance? Sauna use can improve your functional exercise capacity by 32% if you do a 20min post workout sauna.\nMode of action.\nResponse proteins are proteins which are released to try to repair/ protect cells from damage. These are special proteins which are quite common across species.\nHeat shock protein is a response protein. Another example is melatonin. (?Future post idea: if you want me to do a post on this, drop a comment below). It works by helping other proteins maintain their 3D-shape during times of heat stress, protecting the protein from denaturing. Doing this helps prevent the formation of protein aggregates, which form by accumulation of mis-folded proteins, proteins which have lost their proper shape, and then clump together. Protein aggregates are seen in Neuro-degenerative disorders like Alzheimer's, Lewie Body disease, Huntington's, AMD and Parkinson's disease.\nSubsequent research confirms this as the 2-3 sauna/ wk men had 22% lower dementia rate, 4-7/wk was 66% lower risk\nAnother molecular pathway of interest that may help to explain some of what’s going on with this association between a type of longevity and sauna use is a pathway known as the FOXO3 pathway. In Addition to the neurodegenerative disorders listed above, FOXO3 can help protect against Type 2 diabetes, cardiovascular disease and cancer. FOXO3 is a master regulator, and is involved in: autophagy, DNA repair, metabolism, endogenous antioxidant production, stem cell function and Immune function, energy metabolism, oxidative stress, proteostasis, apoptosis, cell cycle regulation, metabolic processes, immunity, inflammation and stem cell maintenance.\nThere is some evidence that part of the natural cellular stress response when confronted with heat is an activation of this pathway. FOXO3 is super important in ageing. Different versions of FOXO3 can result is up to a 2.7-fold increased chance of living to be 100. In mice, having more of their homologous version of this same gene can extend their lifespan by up to 30 percent!\nAs a pattern of aging, our FOXO3 activation trends downward… decreasing in expression with age. A lot of research is going on into how to up-regulate FOXO3 activity. Some success is being found with phytochemicals such as polyphenols and flavinols. For example, rats green tea extract ECGC in drinking water increased sirtuin 1, FOXO3 (by 67-100%), SOD, glutathione peroxidase and lifespan (by 14%!!), reduced NF-κB, IL-6, TNF-α, ROS, inflammation, oxidative stress in serum, liver and kidney, and protected against organ damage. In a human population, it was shown recently that associations between tea drinking and risk for cognitive disability among the oldest old were dependent upon FOXO genotype.\nCurcumin, from turmeric, reduces FOXO3 phosphorylation, resulting in a doubling of FOXO3 gene expression. Curcumin lowers lipid levels in peritoneal macrophages of obese mice. Curcumin, through its actions on increasing FOXO3 activity, may protect against oxidant- and lipid-induced damage in the inflammatory cells of the vascular system, thus reducing the risk for age-associated cardiovascular disease.\n\nIn cultured human skin fibroblasts, resveratrol inhibited the expression of the senescence mediator INK4a. Resveratrol and sirtuin-activating compounds can, in certain cases, delay ageing, age-related diseases and increase lifespan.\n\nSo. Get your self some sauna time regularly, pre-hydrate with green tea and /or concentrated blueberry extract. A bit of curcumin would add the kicker to the mix (usual recommendations for use i.e. dissolved in an oil to aid absorption)",
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      "body": "@@ -257,17 +257,17 @@\n group ..\n-c\n+C\n aucasian\n@@ -268,17 +268,17 @@\n casians/\n-a\n+A\n fricans/\n@@ -282,17 +282,17 @@\n ns/ \n-a\n+A\n sians/ \n-p\n+P\n ersi\n@@ -300,18 +300,17 @@\n ns/ \n-a\n+A\n mazonian\n-s\n ...)\n@@ -341,17 +341,17 @@\n off.  %0Ay\n-p\n+o\n ur post \n@@ -429,17 +429,17 @@\n all the \n-m\n+M\n althusia\n",
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      "body": "the process you are looking for for is called autophagy. It is where your immune system, in the form of phagocytes, search out and consume inefficient/ dying/ damaged cells and harvest their nutrients for reuse in other fresh cells. \nVampire therapy where an aged individual is leached off a youngling, is one way of replacing senescent proteins and cells, but a better way is through intermittent fasting either by way of time restricted eating windows of 8-10 hrs per day, or using something like Longo's fasting mimicking diet (www.prolonfmd.com) which is all the good of fasting without the  downside like sarcopenia (muscle loss) which can be irreversible in some elderly, leading to their demise. (Thankfully this can be mitigated with a daily dose of 1-1.5g branched chain amino acids, and the use of exogenous ketone bodies).  Heat shock proteins are also a way to induce autophagy, although not as powerful. \nThe discussion of autophagy raises a key point about a couple of interesting approaches to anti ageing, namely how long would you run rapalogs for given they inhibit autophagy to certain degree, and allow possible free radical production by cells containing damaged mitochondria leaking from disrupted electron chain pathways? The likely answer may be that we cycle this stuff, and have runs of treatments with an underlying persistent effort to detoxify, and unburden our mitochondria, then initiate mitochondrial biogenesis.",
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      "body": "r u pho real?  if the world is over populated by a virus, are you going to be the next to cell to initiate apoptosis to lower the viral load?? Or are you one of these types that thinks the virus is caused by them... over there .. those... (put in your select group ..caucasians/africans/ asians/ persians/ amazonians...) and elect to kill them off.  \nypur post essentially paints you a Malthusian. Many a sky has not fallen despite all the malthusian's shock and horror. Tech solves our next crisis. Overpopulation is not an issue at all. If you knew anything about demographics you would understand that the west has an issue with depopulation caused by insufficient birth rates. Country by country the western nations are failing to meet the required maintenance birthrate of 2.1 births per woman. The reality is we need anti ageing technologies like OP crytofiend attests, to keep people healthier and in the workplace for longer. The unaccounted for debts represented by various governmental superannuation schemes have every single nation with those structures in place marching head long to bankruptcy. We can avert the issue if we turn to tech and make 100 the new 65. This would allow people to continue to ply their trades/ sell their services/ continue to produce and enhance their communities instead of losing their vital skills to rest homes/ gated communities or geriatric golf courses.\nThere is no reason that those individuals couldn't elect to work for only 3 days a week for 6 months a year and then spend the remainder of the year with their loved ones doing interesting things like visiting the only remaining woven swing bridges in the world which date back to pre Conquistador times. I for one relish the idea of the opportunity of induced tissue regeneration, induced pluripotent stem cells,  telomerase reactivation, peptide therapies, individualised cancer therapies, liquid biopsies all of which are in laboratories today, and are failing to be released because Luddite Malthusians are scared they'll get left behind.",
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