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      "body": "1. Papers\nPapers are the only way that researchers are able to collaborate from around the world and share their methodologies and data for other researchers to potential replicate and validate. Without validation there will be no research being translated so i believe that papers are in fact an essential process to both the research itself and being able to translate it into the real world. Example: Drug companies cannot let drugs go on to clinical development without going through rigourous studies which involve entire rooms of paper containing all of the data needed. \n\n2. Money\nWhile money is a large factor in research and translation into practice because it costs such large amounts for every day that research is being undertaken on a given problem with clinical trials being on example with extremely large costs to run. Companies and governments funding these will obviously take into account the cost and benefit ratios to determine the viability of each potential research area for development. \nIn regards to the comment on coal mining in Australia, I'm an Australian resident and believe that renewable energy is being looked at here however at this time the cost and benefit ratios are obviously still within the range for it to be profitable. Many mine sites in Australia have rehabilitation programs in place that go on for years after mine closure to restore the site to its native state. I believe it will not be long before coal is no longer mined once new research is able to be translated in the renewable energy fields. Once again showing the utter importance for both researchers and translational researchers.",
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      "title": "Psychedelics: Applying cultured 3D neural organoids in studying the effects of DMT on signalling pathways",
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      "title": "Psychedelics: Applying cultured 3D neural organoids in studying the effects of DMT on signalling pathways",
      "body": "![Screen Shot 2017-10-11 at 11.42.23 am.png](https://steemitimages.com/DQmNZKMP1GkvMVeyosxGDWeJDY8rnz9z6fGqErcvm1LNSEe/Screen%20Shot%202017-10-11%20at%2011.42.23%20am.png)\nA study recently published by the D'Or Institute for Research and Education in Brazil has shown to identify a variety of signalling pathways that may be altered by a compound known as 5-MeO-DMT a member of the dimethyltryptamine (DMT) family. The pathways that were found to be altered by 5-MeO-DMT are involved with neurodegenerative processes, inflammation and neural plasticity meaning there is large potential for further preclinical research into the way in which 5-MeO-DMT alters cerebral functioning in both healthy and disease state models. In recent times studies have been completed using a variety of psychedelic compounds such as MDMA and LSD in relation to PTSD and antidepressant therapies, however a lack of quantitative molecular analysis to analyse the targeted pathways has proved difficult to overcome.\n\nIn this recent study completed to measure the effects of 5-MeO-DMT on cerebral organoids, administration of single doses of 5-MeO-DMT to 3D neural cell cultures thought to be representative of the developing human brain were completed. By using quantitative techniques such as mass spectrometry-based proteomics there were 1000's of proteins found to have differing expression levels in response to 5-MeO-DMT administration. The proteins found to have different expression levels were then mapped out in order determine the impact of the alteration of expression by 5-MeO-DMT administration and the roles that they may play in human brain function. Of these proteins identified many played roles in synaptic formation and maintenance and were found to have higher expression levels, some having key relationships to learning and memory both major roles in brain function. \n\nThere were also many proteins found to be implicated in inflammation, degeneration and brain lesions downregulated after 5-MeO-DMT administration pointing to a potential neuroprotective role of DMT. A comment made by a coauthor of the study, Sidarta Ribeiro said \"Results suggest that classic psychedelics are powerful inducers of neuroplasticity, a tool of psychobiological transformation that we know very little about.\" \n\nWith further studies being completed such one there is the potential for further research into the implications of psychedelic use and the potential to identify potential therapeutic targets that psychedelic compounds may be able to target in order to help improve or potential cure some of any of the variety of disease states of the brain that exist such as Parkinsons disease and Alzheimers.\n\n![Screen Shot 2017-10-11 at 11.42.23 am.png](https://steemitimages.com/DQmNZKMP1GkvMVeyosxGDWeJDY8rnz9z6fGqErcvm1LNSEe/Screen%20Shot%202017-10-11%20at%2011.42.23%20am.png)",
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