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      "body": "![fresco-63216_1280.jpg](https://steemitimages.com/DQmQKAxJEFZ1oE3w6CZSimNPybnq5v6qz5APsBU8MzEe3Wk/fresco-63216_1280.jpg)\n\n<hr>\n\n<center>**God's own medicine**</center>\n\n<hr>\n\nMorphine, feted as _“God’s own medicine”_ by Sir William Osler and named after the Greek God of dreams, Morpheus, has been around since ancient times. First extracted from opium in 1806 by the German pharmacist [Friedrich Willhelm Sertürner](https://www.ncbi.nlm.nih.gov/pubmed/12923678), who perfected his extraction procedure for years to come to eventually obtain pure _morphium_ in 1817. Sertürner studied the pharmacological properties of his discovery using himself and stray dogs as test subjects, reporting both the benefits and side effects of morphine in two comprehensive papers. In one of these publications, he described observations made with morphine in humans and for the first time termed it _morphium_. It is this scientific break-through that also earned him a doctoral degree from the university of Jena in 1817. \n\n<hr>\n\n<center>**War and morphine**</center>\n\n<hr>\n\nAlthough being extremely effective at alleviating pain via oral intake, its use increased tremendously when the Scottish physician [Alexander Wood](https://en.wikipedia.org/wiki/Alexander_Wood_(physician)) invented the first true hypodermic syringe in 1853. During the American Civil War, the Seven Weeks’ War and the Franco-Prussian War soldiers were given morphine for almost every ailment under the sun which led to the dangers of addiction and overdose. Things got so out of control that some hospitals even had to hire armed men to guard medicine supplies in order to keep addicts from stealing!\n\n<hr>\n\n<center>**Heroin**</center>\n\n<hr>\n\nBeing such a double-edged sword, pharmaceutical companies started to look for non-addictive alternatives. It was not until 1898 when [Heinrich Dreser](https://en.wikipedia.org/wiki/Heinrich_Dreser), head of pharmacology at Bayer & Co, marketed heroin that they thought they’d finally succeeded. As soon as heroin hit the market, Bayer & Co’s revenue growth skyrocketed. Massive amounts were sold daily and the opiate market flourished. This, however, came at a heavy cost. The first cases of heroin addiction started to pop up and researchers at Bayer & Co knew something was terribly wrong. It turned out that repeated oral administration of heroin resulted in the development of tolerance, eventually leading to both physical and mental addiction. This led to strict regulations in terms of production, distribution and consumption of heroin in 1925. However, the underworld had already recognised the shortage and value of heroin and started to illicitly produce and traffic the substance…and does so ever since.\n\n### [Follow me](https://steemit.com/@jusoran) for your daily dose of science!\n\n<hr>\n\n**References**\nhttp://civilwarrx.blogspot.be/2014/03/about-morphine-use-during-civil-war.html\nhttps://en.wikipedia.org/wiki/Alexander_Wood_\nhttps://en.wikipedia.org/wiki/Friedrich_Sert%C3%BCrner\nhttps://www.ncbi.nlm.nih.gov/pubmed/12923678\nhttps://www.ncbi.nlm.nih.gov/pubmed/11862675\nThe Drug Book. From Arsenic to Xanax, 250 Milestones in the History of Drugs\nhttps://en.wikipedia.org/wiki/Heinrich_Dreser\n\n<hr>\n\n_Picture taken from pixabay.com_",
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      "body": "![Seawater.jpg](https://steemitimages.com/DQmTzzR2WUJPEVkfpstq7JYyrX2PfV7NTzkgBYupQsyvsGq/Seawater.jpg)\n\n… but it’s too difficult to extract it! Almost all of the precious metal is just floating around in seawater and is spread throughout the ocean in mere *parts per trillion*. As the [National Ocean Service](https://oceanservice.noaa.gov/facts/gold.html) puts it:\n\n>\"Each litre of seawater contains, on average, about 13 billionths of a gram of gold.\"\n\nAlthough it doesn’t sound like much, gold is gold, and ever since British chemist [Edward Sonstadt](https://link.springer.com/content/pdf/10.1007%2FBF03215023.pdf) discovered in 1872 that *“the oceans are filled with gold”*, people tried to capitalise on it. Needless to say, I don’t blame them. Based on today’s price of gold, which is about $41 USD per gram, the total amount of gold in the ocean would be worth roughly $744 trillion. That’s right, TRILLION! That’s a whole lot of money to made…if you’re up for the task.\n\n_If you're interested and want to learn more about **gold**, click [here](https://en.wikipedia.org/wiki/Gold)._\n\n### [Follow me](https://steemit.com/@jusoran) for your daily dose of science!\n<hr>\n\n**Source**\nhttps://oceanservice.noaa.gov/facts/gold.html\nhttps://www.atlasobscura.com/articles/gold-ocean-sea-hoax-science-water-boom-rush-treasure\nhttps://link.springer.com/content/pdf/10.1007%2FBF03215023.pdf\n\n<hr>\n\n_Picture taken from pixabay.com and edited by myself_",
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      "body": "I like the idea (i.e. a non-invasive, easy-to-use toxicity endpoint), but, like you mentioned in your post, there's no way this could be extrapolated to human toxicity, which is still the major goal when performing preclinical toxicity studies. Anyway, thanks a lot for this very interesting post!",
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