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      "permlink": "a-sprinkle-of-platinum-nanoparticles-onto-graphene-makes-brain-probes-more-sensitive",
      "title": "A sprinkle of platinum nanoparticles onto graphene makes brain probes more sensitive",
      "body": "<html>This is a low-impedance, transparent graphene microelectrode array. The inset is a microscopic image of the 4 x 4 array. <p>https://cdn.steemitimages.com/DQmRQE7eyfX6TyfAPgBttVH4nYuEPBfhJdgZb7w1kPHWkXY/image.png</p> <p><em></em></p> <p><strong>Graphene electrodes could enable higher quality brain imaging thanks to new research by a team of engineers and neuroscientists. The researchers developed a technique, using platinum nanoparticles, to lower the impedance of graphene electrodes by 100 times while keeping them transparent. In tests on transgenic mice, the electrodes were able to record and image neuronal activity (calcium ion spikes) at of large groups of neurons and individual brain cells.</strong></p> <p><br></p> <p>Graphene electrodes could enable higher quality imaging of brain cell activity thanks to new research by a team of engineers and neuroscientists at the University of California San Diego.</p> <p>The researchers developed a technique, using platinum nanoparticles, to lower the impedance of graphene electrodes by 100 times while keeping them transparent. In tests on transgenic mice, the low-impedance graphene electrodes were able to record and image neuronal activity, such as calcium ion spikes, at both the macroscale and single cell levels. The advance brings graphene electrodes a step closer to being adapted into next-generation brain imaging technologies and various basic neuroscience and medical applications.</p> <p>Over the past five years, researchers have been exploring graphene electrodes for use in neural implants that can be placed directly on the surface of the brain to record neuronal activity. They have several advantages over the traditional metal electrodes used in today's neural implants. They are thinner and flexible, so they can conform better to brain tissue. They are also transparent, which makes it possible to both record and see the activity of neurons directly beneath the electrodes that would otherwise be blocked by opaque metal materials.</p> <p>However, graphene electrodes suffer from high impedance, which means electrical current has difficulty flowing through the material. This hinders communication between the brain and recording devices. Readings are noisy as a result. And while there are various techniques to reduce the impedance of graphene, they ruin the material's transparency.</p> <p>In a new study, an interdisciplinary team of researchers at UC San Diego has developed a technique to engineer graphene electrodes that are both transparent and 100 times lower in impedance. Duygu Kuzum, a professor of electrical and computer engineering at the UC San Diego Jacobs School of Engineering, led the work. Her team developed the low-impedance, transparent graphene electrode arrays. They collaborated with Takaki Komiyama, a professor of neurobiology and neurosciences at the UC San Diego School of Medicine and Division of Biological Sciences, whose team performed brain imaging studies with these electrodes in transgenic mice. The work was published recently in Advanced Functional Materials.</p> <p>'This technique is the first to overcome graphene's electrochemical impedance problem without sacrificing its transparency,' said Kuzum. 'By lowering impedance, we can shrink electrode dimensions down to single cell size and record neural activity with single cell resolution.'</p> <p><br></p> <h3>Lowering impedance</h3> <p>Another important aspect of this work is that it is the first to uncover the root of graphene's high impedance -- a fundamental property called quantum capacitance. It is essentially a limit on how many 'open seats' graphene has to store electrons. And with a limited number of seats dispersed throughout the material, electrons have fewer paths to travel through.</p> <p>Finding a workaround to this limit was key to lowering impedance. Kuzum's team found that by depositing platinum nanoparticles onto graphene's surface, they created an alternate set of paths to channel electron flow.</p> <p><br></p> <p>'We chose platinum because it is a well-established electrode material. It has been used for decades due its low impedance and biocompatibility. And it can be easily deposited onto graphene at low cost,' said first author Yichen Lu, an electrical engineering Ph.D. student in Kuzum's lab at UC San Diego.</p> <p>Researchers also determined an amount of platinum nanoparticles that was just enough to lower impedance while keeping transparency high. With their method, the electrodes retained about 70 percent of their original transparency, which Kuzum notes is still good enough to get high quality readings using optical imaging.</p> <p><br></p> <h3>Recording brain cell activity in mice</h3> <p>Kuzum's team collaborated with neuroscientists in Komiyama's lab to test their electrodes in transgenic mice. Researchers placed an electrode array on the surface of the cortex. They were able to simultaneously record and image calcium ion activity in the brain.</p> <p>In their experiments, they recorded the total brain activity from the surface of the cortex. At the same time, researchers used a two-photon microscope to shine laser light through the electrodes and were able to directly image the activity of individual brain cells at 50 and 250 micrometers below the brain surface. By obtaining both recording and imaging data at the same time, researchers were able to identify which brain cells were responsible for the total brain activity.</p> <p>'This new technology makes it possible to combine macroscale recordings of brain activity, like EEG, with microscopic cellular imaging techniques that can resolve detailed activity of individual brain cells,' said Komiyama.</p> <p>'This work opens up new opportunities to use optical imaging to detect which neurons are the source of the activity that we are measuring. This has not been possible with previous electrodes. Now we have a new technology that enables us to record and image the brain in ways we could not before,' said Kuzum.</p> <p>The team's next steps include making the electrodes smaller and incorporating them into high density electrode arrays.</p> </html>",
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      "title": "Why will bitcoin destroy money? Crypto-currency, as the basis of the economy",
      "body": "What are crypto-currencies? Can they be trusted? Why do we need crypto currency? What is the revolutionary character of crypto currency? How will crypto currencies change the future? Why do crypto currencies support the ideas of libertarianism and anarchocapitalism? When to expect a sharp increase in the cost of crypto currency? All that you wanted to know about crypto-currencies, you will find in today's article.\n\n![photo_2018-08-04_18-22-02.jpg](https://cdn.steemitimages.com/DQmd1jTKx3tBcXAuDm2Rjb3fCBtbwayktutsx7nXJRgUcA3/photo_2018-08-04_18-22-02.jpg)\n\nToday's article is a continuation of our yesterday about the economic problems of our time. What are their solutions? For many years, the ideas of libertarianism and anarcho-capitalism hampered the absence of a decentralized currency, allowing for free trade. So far, no special electronic money has appeared-crypto-currencies, or the crypt.\n\nInitially, the only was bitcoin. Its creator, Satoshi Nakamotoi, adhered to the principles of freedom and equality in the economic sphere. He created a transparent, unregulated network in which everyone could control their own funds and not depend on anyone. Subsequent derivatives of bitcoin are called altcoyins.\n\nThe uniqueness of these unusual money is a complete decentralization, which in the end gives equality between customers. Neither bitcoins nor altcoyins do not exist in reality, but in the form of information in a unique registry called a blockchain. There they are stored on a special address, the password to which is known only to its owner.\n\nIn crypto-currencies, each person is both a user and a manager. This contributes to the preservation of efficiency with a huge number of people online. Tokens (coins) appear as a result of self-service. In order to conduct a transaction, it must be confirmed by a group of random participants. This is done by choosing a digital combination that solves the equation in the blockchain. The process itself is called mining. In fact, the crypt is a by-product of the functioning of the system. It is logical that over time, the rate of appearance of new tokens is reduced, due to the increasing complexity of mathematical problems. What serves as the emission limit.\n\nThe main advantages of the crypt are decentralization and deregulation. These advantages make it possible to carry out transfers safely, eliminating intermediaries and taxes. Users are completely independent and put the software, becomes part of the structure and the right to dispose of their money at will.\n\nSignificant role in the popularity of crypto-currencies was played by anonymity and security. To use crypts, you do not need to enter personal data. Moreover, tokens are used all over the world and you can make deals with people living all over the world. All operations are cryptographically protected, so that they can not be hacked. Payments can not be canceled after they are completed. Outsiders do not have the ability to influence your wallet.\n\nOf course, crypto-currencies contain a number of problems. The main two: a small transaction speed and lack of infrastructure, with which you could pay off in everyday life. Technical progress will solve the first problem, and time and business the second. In the future, both bitcoin and altcoins will grow in price and become a virtual analogue of gold. Some states are actively struggling with this, others are languishing in imitation of interest. However, the convenience of circulation, anonymity and security will contribute to the growth of currency prevalence. That one more step will bring us closer to a libertarian and anarcho-capitalistic future.",
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