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| comment | | "parent_author":"shlizzy",<br>"parent_permlink":"re-point-is-this-protein-molecule-nf-kb-the-key-to-fighting-most-cancers-diseases-chronic-back-pain-asthma-arthritis-and-more-what-foods-20180315t104047848z",<br>"author":"point",<br>"permlink":"re-shlizzy-re-point-is-this-protein-molecule-nf-kb-the-key-to-fighting-most-cancers-diseases-chronic-back-pain-asthma-arthritis-and-more-what-foods-20180315t145344402z",<br>"title":"",<br>"body":"Wow,<br> you're very knowledgeable. Thank you for your insight. \n\nAs for your question,<br> from what I've read,<br> aspirin irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2.\n\nCOX-1 is involved in pain,<br> promoting clotting,<br> and protecting the stomach\nCOX-2 is involved in the pain produced by inflammation\n\nCOX-2 inhibitors (not aspirin) are effective against inflammation and avoid damage to the GI tract,<br> but they increase the risk of blood clots.\n\nAnGes,<br> Inc. is doing a 12 month study injecting a NF-kB Decoy directly into the intervertebral discs of patients with chronic discogenic low back pain (DLBP). Hopefully without the problems of COX inhibitors,<br> but it will most likely come with new side effects.\n\nMore info on all this here:\n1. http:\/\/www.biology-pages.info\/I\/Inflammation.html\n2. https:\/\/en.wikipedia.org\/wiki\/Aspirin\n3. http:\/\/pipelinereview.com\/index.php\/2018022867489\/DNA-RNA-and-Cells\/AnGes-Announces-First-Patient-Treated-with-NF-kappa-B-Decoy-in-Phase-Ib-Study-to-Treat-Discogenic-Low-Back-Pain.html\n\nIf your target is inflammation in the arteries,<br> Nitric Oxide derived from L-arginine supplementation can be very effective. Some are much better than others. I personally like the chocolate chewables CardioForLife at https:\/\/www.healthguardian.com\/product\/name\/cardioforlife\/id\/1930190 \n\nMore info about nitric oxide here:\n4. http:\/\/www.biology-pages.info\/N\/NO.html\n5. https:\/\/en.wikipedia.org\/wiki\/Nitric_oxide#Biological_functions\n\nOOOOPS... My answer got a bit too long and off topic. I need to go now. Thanks again for your comment.",<br>"json_metadata":" \"tags\":[\"steemstem\" ,<br>\"links\":[\"http:\/\/www.biology-pages.info\/I\/Inflammation.html\",<br>\"https:\/\/en.wikipedia.org\/wiki\/Aspirin\",<br>\"http:\/\/pipelinereview.com\/index.php\/2018022867489\/DNA-RNA-and-Cells\/AnGes-Announces-First-Patient-Treated-with-NF-kappa-B-Decoy-in-Phase-Ib-Study-to-Treat-Discogenic-Low-Back-Pain.html\",<br>\"https:\/\/www.healthguardian.com\/product\/name\/cardioforlife\/id\/1930190\",<br>\"http:\/\/www.biology-pages.info\/N\/NO.html\",<br>\"https:\/\/en.wikipedia.org\/wiki\/Nitric_oxide#Biological_functions\" ,<br>\"app\":\"steemit\/0.1\" " |
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